کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1358626 | 981351 | 2012 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms](/preview/png/1358626.png)
New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole.
New oxirane derivatives were synthesized using six naphthoquinones as the starting material. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazoleFigure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 16, 15 August 2012, Pages 4995–5000