Novel antibacterial active quinolone–fluoroquinolone conjugates and 2D-QSAR studies

Novel, quinolone–fluoroquinolone conjugates 10a–f, 11a–f, 13a–f and 14a–f with amino acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial bioassay showed the synthesized bis-conjugates exhibit anti-bacterial properties comparable with the parent drugs.

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