کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1358820 | 981369 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors](/preview/png/1358820.png)
چکیده انگلیسی
A series of novel fused heterocycle methyl esters were designed and synthesized as human nonpancreatic secretory phospholipase A2 (hnps-PLA2) competitive inhibitors. Among the 22 synthesized compounds, 17 quinoline-4-methyl esters displayed hnps-PLA2 inhibition activity in the in vitro bioassay. The IC50 value for the best compound 3o was 1.5 μM. The structure-inhibition–activity relationships of the compounds were studied using molecular docking.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 11, 1 June 2011, Pages 3361–3366
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 11, 1 June 2011, Pages 3361–3366
نویسندگان
Yiran Wu, Zheng Chen, Ying Liu, Lanlan Yu, Lu Zhou, Suijia Yang, Luhua Lai,