کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1358820 981369 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors
چکیده انگلیسی

A series of novel fused heterocycle methyl esters were designed and synthesized as human nonpancreatic secretory phospholipase A2 (hnps-PLA2) competitive inhibitors. Among the 22 synthesized compounds, 17 quinoline-4-methyl esters displayed hnps-PLA2 inhibition activity in the in vitro bioassay. The IC50 value for the best compound 3o was 1.5 μM. The structure-inhibition–activity relationships of the compounds were studied using molecular docking.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 11, 1 June 2011, Pages 3361–3366
نویسندگان
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