کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1359209 | 981397 | 2009 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of acrylic acids and their structurally related compounds were evaluated for their binding affinity to four EP receptor subtypes (EP1-4). Starting from the initial hit 3, which was discovered in our in-house library, compounds 4 and 5 were identified as new chemical leads as candidates for further optimization towards a selective EP3 receptor antagonist. The identification process of these compounds and their pharmacokinetic profiles are presented.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 18, 15 September 2009, Pages 6567–6582
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 18, 15 September 2009, Pages 6567–6582
نویسندگان
Masaki Asada, Tetsuo Obitsu, Toshihiko Nagase, Isamu Sugimoto, Yoshiyuki Yamaura, Kazutoyo Sato, Masami Narita, Shuichi Ohuchida, Hisao Nakai, Masaaki Toda,