Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part

An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a–t) containing substituents such as methoxy, hydroxyl, and halogen (F, Cl, and Br) on indeno part was described. Antioxidant and radical scavenging activities of synthesized compounds (3a–t) were determined by various in vitro assays such as 1,1-diphenyl-2-picryl-hydrazyl free radicals (DPPH), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radicals (ABTS+), N,N-dimethyl-p-phenylenediamine dihydrochloride radicals (DMPD+), and superoxide anion radicals (O2-) scavenging, reducing ability determination by the Fe3+–Fe2+ and Cu2+–Cu+ (CUPRAC method) transformation methods, H2O2 scavenging, and ferrous ion (Fe2+) chelating activities. Moreover, these activities were compared to synthetic and standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocopherol, and trolox. The results showed that the synthesized compounds (3a–t) had effective antioxidant power.

Antioxidant activity and synthesis of new 5,10-dihydroindeno[1,2-b]indoles are reported.Figure optionsDownload as PowerPoint slide