Solution-phase parallel synthesis of substituted chalcones and their antiparasitary activity against Giardia lamblia

A library of 25-membered chalcones was prepared by parallel synthesis. Substituted acetophenones and benzaldehydes were condensed using the Claisen–Schmidt base-catalyzed aldol condensation. Several chalcones showed in vitro antiparasitic activity against Giardia lamblia. The highest activity observed for the IC50 values were 12.72, 15.05 and 15.31 μg/mL, respectively; these are potential leads for the development of antigiardial compounds.

A library of 25-membered chalcones was prepared by parallel synthesis. Three chalcones showed in vitro antiparasitic activity against Giardia lamblia These are potential leads for the development of antigiardial compounds.Figure optionsDownload as PowerPoint slide