کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1359507 1500521 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of 6″-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of 6″-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands
چکیده انگلیسی

We report the synthesis of a small series of 6”-triazol-1-yl-substituted α-GalCer analogues by late-stage conversion of the 6”-OH to an azide group, copper-catalyzed azide-alkyne cycloaddition and final deprotection. When evaluated for their capacity to induce IL-2 secretion in vitro, all compounds proved equally potent or superior to α-GalCer. The S.A.R suggests that the improved antigenic activity is mainly triggered by the triazole functionalization in se. While the introduction of selected substitutuents at C-4 of this heterocyclic ring is tolerated, this generally fails to further improve antigenicity.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 24, 15 December 2012, Pages 7149–7154
نویسندگان
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