کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1359652 | 981408 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents
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کلمات کلیدی
LDA, lithium diisopropylamideDIEA, diisopropylethylamine - DIEA، diisopropylethylamineHER2, human epidermal growth factor receptor 2 - HER2، گیرنده عامل فاکتور رشد اپیدرمی انسان 2SAR, Structure?activity relationship - SAR، رابطه ساختار و فعالیتTAM, tamoxifen - TAM، تاموکسیفنer, estrogen receptor - است، گیرنده استروژن
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents](/preview/png/1359652.png)
چکیده انگلیسی
6-Phenyl-4H-furo[3,2-c]pyran-4-one derivatives based on neo-tashinlactone (1) were synthesized and evaluated as novel anti-breast cancer agents. Compounds 10–13, 23, 25, and 27 showed potent inhibition against the SK-BR-3 breast cancer cell line. Importantly, 25 and 27 showed the highest cancer cell line selectivity, being approximately 100–250-fold more potent against SK-BR-3 (ED50 0.28 and 0.44 μM, respectively) compared with other cancer cell lines tested. In addition, 25 displayed low cytotoxicity against normal breast cell lines 184A1 and MCF10A. Compounds 25 and 27 merit further investigation in our continuing program to generate and develop selective anti-breast cancer agents.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 2, 15 January 2010, Pages 803–808
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 2, 15 January 2010, Pages 803–808
نویسندگان
Yizhou Dong, Qian Shi, Kyoko Nakagawa-Goto, Pei-Chi Wu, Susan L. Morris-Natschke, Arnold Brossi, Kenneth F. Bastow, Jing-Yu Lang, Mien-Chie Hung, Kuo-Hsiung Lee,