کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1359653 981408 2010 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Click synthesis of estradiol–cyclodextrin conjugates as cell compartment selective estrogens
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Click synthesis of estradiol–cyclodextrin conjugates as cell compartment selective estrogens
چکیده انگلیسی

Cyclodextrin (CD) is a well known drug carrier and excipient for enhancing aqueous solubility. CDs themselves are anticipated to have low membrane permeability because of relatively high hydrophilicity and molecular weight. CD derivatization with 17-beta estradiol (E2) was explored extensively using a number of different click chemistries and the cell membrane permeability of synthetic CD–E2 conjugate was explored by cell reporter assays and confocal fluorescence microscopy. In simile with reported dendrimer–E2 conjugates, CD–E2 was found to be a stable, extranuclear receptor selective estrogen that penetrated into the cytoplasm.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 2, 15 January 2010, Pages 809–821
نویسندگان
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