Synthesis of puromycin derivatives with backbone-elongated substrates and associated translation inhibitory activities

We have synthesized a series of 5′-phosphorylated and 5′-cytidylyl-(3′–5′)-cytidylyl-(3′–5′)-puromycin derivatives that have backbone-elongated substrates. All the synthesized puromycin derivatives showed good solubility in water and were applied to translation inhibitory assay in a reconstituted Escherichia coli translation system.

The synthesis of puromycin derivatives with backbone-elongated substrates is reported.Figure optionsDownload as PowerPoint slide