کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1360195 981428 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ceramides: Branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Ceramides: Branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency
چکیده انگلیسی

The synthesis of a small number of ceramide analogues containing a combination of linear and highly branched alkyl chains on either the d-sphingosine or the N-acyl core of the molecule is reported. Regardless of location, the presence of the branched chain improves potency relative to the positive control, C2 ceramide; however, the most potent compound (4) has the branched side chain as part of the d-sphingosine core. The induction of apoptosis by 4 in terms of Annexin V binding and DiOC6 labeling was superior to that achieved with C2 ceramide.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 4, 15 February 2009, Pages 1498–1505
نویسندگان
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