کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1360368 981434 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis
چکیده انگلیسی

Neolignans such as obovatol, honokiol, and magnolol have been previously reported to show various biological activities including anti-inflammation and antitumor effects. This is the first demonstration on the in vivo antitumor effect of obovatol on human colorectal carcinoma SW620 cells. Nude mice were implanted with SW620 cells and fed with vehicle or 5 mg/kg/d dose of obovatol for 20 days. Obovatol inhibited tumor growth that accounted for 50% decrease in tumor volume and 44.6% decrease in tumor weight at the end of the experiment without any adverse health effect. In nude mice bearing SW620-incubated tumor, obovatol exhibited more potent antitumor activity than honolkiol. In addition, DNA flow cytometric analysis shows that obovatol progresses to apoptosis as detected by flow cytometry after double staining with annexin V and propidium iodide. Thus, we suggest that obovatol is a potent inducer of cell apoptosis in SW620 cells, and a potent antitumor agent.

Obovatol inhibited tumor growth and exhibited more potent anti-tumor activity than honokiol in nude mice experiment bearing SW620-incubated tumor.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 18, 15 September 2008, Pages 8397–8402
نویسندگان
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