کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1360454 | 981437 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives](/preview/png/1360454.png)
چکیده انگلیسی
New phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields (70–90%). All compounds (3a–l) were evaluated against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility. The compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 μg/mL, respectively, and could be considered new lead compounds in the treatment of tuberculosis and multi-drug resistant tuberculosis.
A series of phthalimide derivatives were evaluated against Mycobacterium tuberculosis H37Rv and the compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 μg/mL.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 11, 1 June 2009, Pages 3795–3799
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 11, 1 June 2009, Pages 3795–3799
نویسندگان
Jean L. Santos, Paulo R. Yamasaki, Chung Man Chin, Célio H. Takashi, Fernando R. Pavan, Clarice Q.F. Leite,