کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1360518 981438 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety
چکیده انگلیسی

The antifungal activity of several di(hetero)arylamine derivatives of the benzo[b]thiophene system was evaluated against clinically relevant Candida, Aspergillus, and dermatophyte species by a broth macrodilution test based on CLSI (formerly NCCLS) guidelines. The most active compound showed a broad spectrum of activity (against all tested fungal strains, including fluconazole-resistant fungi), with particularly low MICs for dermatophytes. Results from the inhibition of the dimorphic transition in Candida albicans and flow cytometry studies further confirmed their biological activity. With this study it was possible to establish some structure–activity relationships (SARs). The hydroxy groups proved to be essential for the activity in the aryl derivatives. Furthermore, the spectrum of activity in the pyridine derivatives was broadened by the absence of the ester group on position 2 of the benzo[b]thiophene system.

The antifungal activity of new synthesized di(hetero)arylamine derivatives of benzo[b]thiophene, together with some previously reported ones, was evaluated against relevant Candida, Aspergillus, and dermatophyte species and further confirmed through flow cytometry and germ tube inhibition in Candida albicans.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 17, 1 September 2008, Pages 8172–8177
نویسندگان
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