کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1360803 981448 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel naphthalimide–amino acid conjugates with flexible leucine moiety as side chain: Design, synthesis and potential antitumor activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel naphthalimide–amino acid conjugates with flexible leucine moiety as side chain: Design, synthesis and potential antitumor activity
چکیده انگلیسی

A series of novel naphthalimide derivatives with flexible leucine side chains were designed and synthesized. Their antitumor activities were evaluated against HeLa, A549, P388, HL-60, MCF-7, HCT-8 and A375 cancer cell lines in vitro. The preliminary results showed that most of the derivatives had moderate antitumor activities with the IC50 values of 10−6–10−5 M. More importantly, compounds 8a–c exhibited exclusive antitumor activities against MCF-7 cell line. The interaction between compound 8b and BSA was also investigated. DNA binding experiments showed that these derivatives behaved as DNA intercalating agents. This work provided a novel class of naphthalimide-based lead compounds with exclusive antitumor activities against MCF-7 cell line for further optimization.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 2, 15 January 2009, Pages 592–599
نویسندگان
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