کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1360901 981452 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes
چکیده انگلیسی

Water-soluble non-conjugated thienyl tetraynes (3–6) were synthesized and their DNA cleaving activity was evaluated using electrophoresis, atomic force microscopy (AFM) and Escherichia coli (E. coli) transformation techniques. The amino-functionalized compound 4 was shown to possess an activity to cleave plasmid DNA by both electrophoresis and E. coli transformation techniques. AFM also showed a cleavage of the circular DNA into a linear form with a formation of burst-star-shaped architectures, which were envisaged to be cross-linked DNA oligomers.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 10, 15 May 2008, Pages 5441–5451
نویسندگان
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