کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1361034 | 981456 | 2008 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones](/preview/png/1361034.png)
A series of naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups have been prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. The members of these series were tested on normal human fibroblasts and on a panel of four human cancer cell lines. Antitumor activities, which were in the range of IC50 1.3–89.5 μM, discussed in terms of LUMO energy, lipophilicity and size of the polyoxyethylene moiety.
Naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups (5, 7–9) were prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. These compounds were tested on normal human fibroblasts and on a panel of four human cancer cell lines. Antitumor activities, which were in the range of IC50 1.3–89.5 μM, are discussed in terms of LUMO energy, lipophilicity, and size of the polyoxyethylene moiety.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 7, 1 April 2008, Pages 3687–3693