کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1361038 | 981456 | 2008 | 7 صفحه PDF | دانلود رایگان |
A novel elemanolide with an α-methyl-γ-lactone moiety, 8α-O-(4-hydroxy-2-methylenebutanoyloxy)melitensine, in addition to four known sesquiterpene lactones also bearing the same lactone ring, melitensin, 11β,13 dihydrosalonitenolide, 8α-hydroxy-11β,13-dihydro-4-epi-sonchucarpolide, and 8α-hydroxy-11β,13-dihydro-onopordaldehyde have been isolated from the aerial parts of Centaurea pullata. The in vitro antibacterial and antifungal activities of the isolated sesquiterpene lactones were tested against six bacteria and eight fungal species, using a microdilution method. All compounds tested showed greater antibacterial and antifungal activities than the positive controls used. Moreover, the pharmacokinetic profile of these compounds was investigated using computational methods.
8α-O-(4-Hydroxy-2-methylenebutanoyloxy)melitensine. A novel elemanolide with an α-methyl-γ-lactone moiety isolated from Centaurea pullata.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 7, 1 April 2008, Pages 3725–3731