Synthesis and antiviral activities of novel chiral cyanoacrylate derivatives with (E) configuration

The intermediate 3 is converted by the nucleophilic attack of the appropriate aryl (heterocyclic) amine under microwave irradiation into the chiral (E) isomers of title compound 4. These compounds exhibited weak to good anti-TMV bioactivity with (R)-4p showing significant enhancement of disease resistance in tobacco leaves.

Nucleophilic attack of the appropriate amine under microwave irradiation on 3 generates the chiral (E) isomers of title compound 4 exhibiting weak to good anti-TMV bioactivity, (R)-4p showing significant enhancement of disease resistance in tobacco leaves.Figure optionsDownload as PowerPoint slide