Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines

Novel ω-oxygenated vitamin K2 analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in γ-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure–activity relationship of vitamin K2 analogues for the development of new drugs.

Novel ω-oxygenated vitamin K2 analogues were efficiently synthesized and their biological activities were evaluated.Figure optionsDownload as PowerPoint slide