کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1361385 981462 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species
چکیده انگلیسی

2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of these compounds has been raised as a matter of interest. Thus the present work consisted in the study of the in vitro scavenging activities for reactive oxygen species (ROS) and reactive nitrogen species (RNS) of various 2-styrylchromone derivatives and structurally similar flavonoids. Some of the studied 2-styrylchromones proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases, IC50s under 1 μM. The hydroxylation pattern of 2-styrylchromones, especially in the B-ring but also in the A ring, modulates the activity of these compounds, the catecholic derivatives being the most effective scavengers. The styryl pattern also contributes to their observed outstanding antioxidant activity. In conclusion, the scavenging activities for ROS/RNS of 2-styrylchromone derivatives, here shown for the first time, provide novel and most promising compounds to be applied as antioxidants.

2-Styrylchromones were tested for their scavenging activity against ROS and RNS. Some of the studied compounds proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases, IC50s under 1 μM.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 18, 15 September 2007, Pages 6027–6036
نویسندگان
, , , , , , ,