کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1361407 981462 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular design of anti-MRSA agents based on the anacardic acid scaffold
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Molecular design of anti-MRSA agents based on the anacardic acid scaffold
چکیده انگلیسی

A series of anacardic acid analogues possessing different side chains viz. phenolic, branched, and alicyclic were synthesized and their antibacterial activity tested against methicillin-resistant Staphylococcus aureus (MRSA). The maximum activity against this bacterium occurred with the branched side-chain analogue, 6-(4′,8′-dimethylnonyl)salicylic acid, and the alicyclic side-chain analogue, 6-cyclododecylmethyl salicylic acid, with the minimum inhibitory concentration (MIC) of 0.39 μg/mL, respectively. This activity was superior to that of the most potent antibacterial anacardic acid isolated from the cashew Anacardium occidentale (Anacardiaceae), apple and nut, that is, the 6-[8′(Z),11′(Z),14′-pentadecatrienyl]salicylic acid.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 18, 15 September 2007, Pages 6236–6241
نویسندگان
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