کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1361408 981462 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
2D Quantitative structure–activity relationship studies on a series of cholesteryl ester transfer protein inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
2D Quantitative structure–activity relationship studies on a series of cholesteryl ester transfer protein inhibitors
چکیده انگلیسی

Coronary heart disease (CHD) is one of the major causes of human death. The most successful therapeutic approach available is based on the reduction of low density-lipoprotein cholesterol (LDL-C). However, it is believed that the next paradigm in CHD treatment will rely on increased HDL-C levels. One of the most promising strategies for this goal is the inhibition of cholesteryl ester transfer protein (CETP). In the present work, robust classical 2D QSAR (r2 = 0.76, q2 = 0.72) and hologram QSAR (r2 = 0.88, q2 = 0.70) models were developed for a series of 85 CETP inhibitors (N-N-disubstituted trifluoro-3-amino-2-propanol derivatives). These models are complementary in nature and highlight important structural features for the design of novel CETP inhibitors with improved potency.

Classical 2D QSAR (r2 = 0.76, q2 = 0.72) and hologram QSAR (r2 = 0.88, q2 = 0.70) models were developed for a series of 85 CETP inhibitors (N-N-disubstituted trifluoro-3-amino-2-propanol derivatives). These models are complementary in nature and highlight important structural features for the design of novel CETP inhibitors with improved potency.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 18, 15 September 2007, Pages 6242–6252
نویسندگان
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