Second generation of α-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization

Synthesis, physicochemical, and biological characterization of a series of α-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic–hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.

Synthesis, physicochemical, and biological characterization of second generation series of products obtained by coupling α-tocopherol or analogs through appropriate spacers with the NO-donor either nitrooxy or furoxan moieties were described.Figure optionsDownload as PowerPoint slide