Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: Synthesis and structure-activity relationships

The synthesis and Gly/NMDA, AMPA and KA receptor binding activities of a new set of 1,9-disubstituted-8-chloro-pyrazolo[1,5-c]quinazoline-2-carboxylates designed as AMPA and KA receptor antagonists are described.