کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1361553 981466 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proteasome inhibition by peptide-semicarbazones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Proteasome inhibition by peptide-semicarbazones
چکیده انگلیسی

Peptide-semicarbazones derived from Z-Trp-Trp-Phe-aldehyde inhibit the chymotryptic activity of the human proteasome at nanomolar concentrations, but are less active in a NFκB reporter gene assay. Cyclic semicarbazones, in contrast, combine a strong inhibitory effect on the enzyme with an inhibition of NFκB signaling in the nanomolar range. In addition, a practical synthesis for scale-up of such compounds was developed.

Z-Trp-Trp-Phe-cyclic semicarbazone peptides inhibit the chymotryptic activity of the human proteasome at nanomolar concentrations.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 8, 15 April 2008, Pages 4579–4588
نویسندگان
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