کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1361584 | 981467 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of antibacterial and antiviral activities of novel fused 1,2,4-triazine esters
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification of antibacterial and antiviral activities of novel fused 1,2,4-triazine esters Identification of antibacterial and antiviral activities of novel fused 1,2,4-triazine esters](/preview/png/1361584.png)
چکیده انگلیسی
Biological activities of the designed novel fused 1,2,4-triazine esters (3a, 3d-j) are reported. In particular, heterobicycles 3d and 3e revealed comparable antibacterial potencies in vitro to that of ampicillin. Compounds 3e, 3g and 3j exhibited antiviral activities against the selected viruses' DNA (human adenovirus type 5-Ad-5) or/and RNA (human enterovirus Echo-9). Simultaneously, their cytotoxicities towards the normal HEK-293 and GMK cells were established. In particular, heterobicycle 3j, non-toxic for GMK cells, was found to exhibit virucidal properties against Echo-9 virus justifying its further investigation as the potential antiviral agent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 16, 15 August 2007, Pages 5480-5486
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 16, 15 August 2007, Pages 5480-5486
نویسندگان
Krzysztof Sztanke, Kazimierz Pasternak, Barbara Rajtar, MaÅgorzata Sztanke, Magdalena Majek, MaÅgorzata Polz-Dacewicz,