کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1361844 | 981472 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity](/preview/png/1361844.png)
چکیده انگلیسی
A series of pyrrolidinones derived from phenylalanines were synthesized as potent antagonists of the human melanocortin-4 receptor. These compounds showed high potencies and selectivities, and several of them had good oral bioavailabilities. In addition, 12e demonstrated in vivo efficacy in a murine cachexia model.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 15, 1 August 2007, Pages 5166–5176
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 15, 1 August 2007, Pages 5166–5176
نویسندگان
Joe A. Tran, Fabio C. Tucci, Wanlong Jiang, Dragan Marinkovic, Caroline W. Chen, Melissa Arellano, Stacy Markison, Beth A. Fleck, Jenny Wen, Nicole S. White, Joseph Pontillo, John Saunders, Daniel Marks, Sam R. Hoare, Ajay Madan, Alan C. Foster,