Keywords: گیرنده ملانوکورتین-4; α-MSH; α-melanocyte stimulating hormone; AGRP; agouti related protein; ARC; arcuate nucleus of hypothalamus; ATF; activating transcription factor; BBB; blood-brain barrier; CRH; corticotropin-releasing hormone; CSF; cerebrospinal fluid; Cys; cysteine; D
مقالات ISI گیرنده ملانوکورتین-4 (ترجمه نشده)
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Keywords: گیرنده ملانوکورتین-4; Melanocortin-3 receptor; Melanocortin-4 receptor; Obesity; Energy homeostasis; Biased signaling; AgRP;
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Ligand binding; Signaling; Chicken; Mutation;
Keywords: گیرنده ملانوکورتین-4; AgRP; agouti-related peptide; α-MSH; α-melanocyte stimulating hormone; CNS; central nervous system; COR; Contrave Obesity Research; DIO; diet-induced obese; fMRI; functional magnetic resonance imaging; MC4R; melanocortin-4 receptor; MOP-R; μ-opioid rec
Keywords: گیرنده ملانوکورتین-4; αMSH; α-melanocyte stimulating hormone; ACTH; adrenocorticotrophic hormone; AgRP; agouti-related peptide; ARC; arcuate nucleus; AVPV; anteroventral periventricular area; BMI; body mass index; BMR; basal metabolic rate; CART; cocaine amphetamine related
Keywords: گیرنده ملانوکورتین-4; BDA; biotin dextran amine; CTb; cholera toxin b subunit; DAB; diaminobenzidine tetrahydrochloride; GFP; green-fluorescent protein; LH; luteinizing hormone; MC4-R; melanocortin-4 receptor; PBS; phosphate-buffered saline; PMv; ventral premammillary nucleus;
Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology
Keywords: گیرنده ملانوکورتین-4; ACTH; Adrenocorticotropic hormone; AgRP; Agouti-related protein; α-MSH; α-melanocyte-stimulating hormone; BSA; bovine serum albumin; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CNS; central nervous system; DMEM; Dulbecco's Modified Eagle Medium; ECL
Fructo-oligosaccharides reduce energy intake but do not affect adiposity in rats fed a low-fat diet but increase energy intake and reduce fat mass in rats fed a high-fat diet
Keywords: گیرنده ملانوکورتین-4; Fructo-oligosaccharide; High-protein diet; High-fat diet; Energy intake; Adiposity; exp1; experiment 1; exp2; experiment 2; NP; normal protein normal fat; NP-FOS; normal protein normal fat with fructo-oligosaccharide; HP; high protein normal fat; HP-FOS;
Role of the brain melanocortins in blood pressure regulation
Keywords: گیرنده ملانوکورتین-4; Hypertension; Sympathetic activity; Obesity; Pro-opiomelanocortin; Melanocortin-4 receptor;
Molecular cloning, tissue distribution, and pharmacological characterization of melanocortin-4 receptor in grass carp (Ctenopharyngodon idella)
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Expression; Ligand binding; Signaling; Grass carp;
Pharmacological chaperones for the misfolded melanocortin-4 receptor associated with human obesity
Keywords: گیرنده ملانوکورتین-4; AgRP; agouti-related peptide; V2R; vasopressin V2 receptor; CFTR; cystic fibrosis transmembrane conductance regulator; ER; endoplasmic reticulum; GnRHR; gonadotropin-releasing hormone receptor; GPCR; G protein-coupled receptor; Hsc70; cytosolic cognate 70
Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer
Keywords: گیرنده ملانوکورتین-4; BMI; body mass index; CCFR; Colon Cancer Family Registry; CI; confidence interval; FTO; fat-mass and obesity-associated; GECCO; Genetics and Epidemiology of Colorectal Cancer Consortium; GWAS; genome-wide association study; MAF; minor allele frequency; MC
Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors
Keywords: گیرنده ملانوکورتین-4; Melanocortin-3 receptor; Melanocortin-4 receptor; Agouti-related peptide; Biased signaling;
Effects of genetic variants for the swine FABP3, HMGA1, MC4R, IGF2, and FABP4 genes on fatty acid composition
Keywords: گیرنده ملانوکورتین-4; SNP; single nucleotide polymorphism; FABP3; fatty acid binding protein 3; HMGA1; high mobility group AT-hook 1; MC4R; melanocortin-4 receptor; IGF2; insulin-like growth factor-2; FABP4; fatty acid binding protein 4; QTL; quantitative trait locus; SFA; sat
HQSAR and topomer CoMFA for predicting melanocortin-4 receptor binding affinities of trans-4-(4-chlorophenyl) pyrrolidine-3-carboxamides
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Binding affinity; Hologram QSAR; Topomer CoMFA; Docking; Piperazinecyclohexanes;
Activation of MAPK by inverse agonists in six naturally occurring constitutively active mutant human melanocortin-4 receptors
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Inverse agonist; Biased signaling; Constitutive activity;
Research ReportIntrapancreatic ganglia neurons receive projection fibers from melanocortin-4 receptor-expressing neurons in the dorsal motor nucleus of the vagus nerve of the mouse
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Green fluorescent protein; Dorsal motor nucleus of the vagus nerve; Intrapancreatic ganglia; Mouse;
Weight-Independent Effects of Roux-en-Y Gastric Bypass on Glucose Homeostasis via Melanocortin-4 Receptors in Mice and Humans
Keywords: گیرنده ملانوکورتین-4; Weight-Loss Surgery; Stomach; Mouse Model; Insulin Sensitivity; CRWM-sham; calorie-restricted, weight-matched sham; DIO; diet-induced obesity; DMV; dorsal motor vagus; HFD; high-fat diet; HOMA-IR; homeostasis model assessment - insulin resistance; IML; in
The effects of leptin receptor (LEPR) and melanocortin-4 receptor (MC4R) polymorphisms on fat content, fat distribution and fat composition in a Duroc Ã Landrace/Large White cross
Keywords: گیرنده ملانوکورتین-4; Leptin receptor; Melanocortin-4 receptor; Mutation; Fat content; Pork; Cured meat products;
The contribution of serotonin 5-HT2C and melanocortin-4 receptors to the satiety signaling of glucagon-like peptide 1 and liragultide, a glucagon-like peptide 1 receptor agonist, in mice
Keywords: گیرنده ملانوکورتین-4; GLP-1; Liraglutide; GLP-1 receptor; 5-HT2C receptor; Melanocortin-4 receptor; Food intake; Body weight;
Alternative G protein coupling and biased agonism: New insights into melanocortin-4 receptor signalling
Keywords: گیرنده ملانوکورتین-4; ACTH; adrenocorticotropic hormone; cAMP; cyclic 3â²,5â²-adenosine monophosphate; AGRP; agouti-related protein; CTX; cholera toxin; ER; endoplasmic reticulum; ERK-1/2; extracellular signal-regulated kinases; FSK; forskolin; GPCR; G protein-coupled recept
Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; MC4R; cAMP assay; Allosteric modulator; High throughput screen
Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis
Keywords: گیرنده ملانوکورتین-4; Melanotan II; Siberian hamster; Melanocortin-4 receptor; HS024; Interscapular brown adipose tissue; Cyclo [ß-Ala-His-D-Phe-Arg-Trp-Glu]-NH2
QSAR study on melanocortin-4 receptors by support vector machine
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; QSAR; Support vector machine; Genetic algorithms; Multiple linear regression; Chemometrics
Classification study of novel piperazines as antagonists for the melanocortin-4 receptor based on least-squares support vector machines
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Antagonist; Bis-piperazines; Linear discriminant analysis; Least-squares support vector machine;
Plasmon-waveguide resonance studies of ligand binding to integral proteins in membrane fragments derived from bacterial and mammalian cells
Keywords: گیرنده ملانوکورتین-4; G-protein-coupled receptors; Bacterial chromatophores; Transfected HEK cells; Rat trigeminal ganglion; μ-Opioid receptor; Cannabinoid CB1 receptor; Melanocortin-4 receptor;
Interactions between genes involved in growth and muscularity in pigs: IGF-2, myostatin, ryanodine receptor 1, and melanocortin-4 receptor
Keywords: گیرنده ملانوکورتین-4; Interactions; IGF-2; Myostatin; Melanocortin-4 receptor; Ryanodine receptor 1
Antibodies as pharmacologic tools for studies on the regulation of energy balance
Keywords: گیرنده ملانوکورتین-4; Immunization; Melanocortin-4 receptor; Food intake; Anorexia; Lipopolysaccharide; G-protein-coupled receptor; Inverse agonist;
Syntheses of tetrahydrothiophenes and tetrahydrofurans and studies of their derivatives as melanocortin-4 receptor ligands
Keywords: گیرنده ملانوکورتین-4; Synthesis; Tetrahydrothiophene; Tetrahydrofuran; Melanocortin-4 receptor; Cyclization; Heterocycle; Piperazinebenzylamine; Stereoisomer; Binding affinity
High-level expression and purification of the second transmembrane domain of wild-type and mutant human melanocortin-4 receptor for solid-state NMR structural studies
Keywords: گیرنده ملانوکورتین-4; Transmembrane protein; Melanocortin-4 receptor; Solid-state NMR; Expression; Purification; Human membrane protein
Pharmacological analyses of two naturally occurring porcine melanocortin-4 receptor mutations in domestic pigs
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Ligand binding; Signaling; Porcine; Naturally occurring mutations;
Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands
Keywords: گیرنده ملانوکورتین-4; Synthesis; Pyrrolidine; Melanocortin-4 receptor; Stereoisomer; Structure–activity relationship
Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Agonist; Antagonist; Potency; Stereochemistry; Pyrrolidine; Obesity; Animal model
Pharmacological and pharmacokinetic characterization of 2-piperazine-α-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Antagonist; Pharmacokinetics; Cachexia; SAR
Involvement of alpha-melanocyte stimulating hormone (α-MSH) in differential ethanol exposure and withdrawal related depression in rat: Neuroanatomical–behavioral correlates
Keywords: گیرنده ملانوکورتین-4; Alpha-melanocyte stimulating hormone; Ethanol; Melanocortin-4 receptor; Withdrawal depression; Forced swim test; Immunocytochemistry
Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor
Keywords: گیرنده ملانوکورتین-4; Pyrrolidinone; Melanocortin-4 receptor; Antagonist; Cachexia; CYP3A4 enzyme; Lipophilicity; Pharmacokinetics;
Homozygous Null Mutation of the Melanocortin-4 Receptor and Severe Early-Onset Obesity
Keywords: گیرنده ملانوکورتین-4; AGRP; Agouti related peptide; alpha-MSH; alpha-melanocyte stimulating hormone; BMI; Body mass index; BMI-Z; Body mass index Z-score; LEPR; Leptin receptor; MC4R; Melanocortin-4 receptor; PCR; Polymerase chain reaction;
Pyrrolidines as potent functional agonists of the human melanocortin-4 receptor
Keywords: گیرنده ملانوکورتین-4; Pyrrolidine; Melanocortin-4 receptor; Agonist; Synthesis
Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Antagonist; Benzimidazole
Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor
Keywords: گیرنده ملانوکورتین-4; Synthesis; Pyrrolidine; Melanocortin-4 receptor; Agonist; Antagonist; Potency; Efficacy
Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor
Keywords: گیرنده ملانوکورتین-4; Synthesis; Pyrrolidine; Melanocortin-4 receptor; Agonist; Antagonist; Structure–activity relationship
Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity
Keywords: گیرنده ملانوکورتین-4; Pyrrolidinone; Synthesis; Melanocortin-4 receptor; Antagonist; Pharmacokinetics; Cachexia; Animal model
Propionylpiperazines as human melanocortin-4 receptor ligands
Keywords: گیرنده ملانوکورتین-4; Propionylpiperazine; Melanocortin-4 receptor; Antagonist; Pharmacokinetic
Activation of the Melanocortin-4 Receptor Mobilizes Intracellular Free Calcium in Immortalized Hypothalamic Neurons1
Keywords: گیرنده ملانوکورتین-4; melanocortin-4 receptor; GT1-1 cells; calcium; G-protein; NDP; MSH; protein kinase C
Role of melanocortin in the long-term regulation of energy balance: Lessons from a seasonal model
Keywords: گیرنده ملانوکورتین-4; α-MSH; α-melanocyte stimulating hormone; AGRP; Agouti-related protein; ARC; arcuate nucleus; CART; cocaine- and amphetamine-regulated transcript; CRF; corticotrophin-releasing factor; icv; intracerebroventricular; LHA; lateral hypothalamus; MC3-R; melan
Obesity-associated mutations in the human melanocortin-4 receptor gene
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Obesity; Mutations; Anti-obesity drug therapy
Participation of α-melanocyte stimulating hormone in ethanol-induced anxiolysis and withdrawal anxiety in rats
Keywords: گیرنده ملانوکورتین-4; Ethanol; Melanocortin-4 receptor; Anxiety; α-Melanocyte stimulating hormone; HS014; Withdrawal anxiety
Structure–activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Cyclohexylpiperazine; Antagonist
Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines
Keywords: گیرنده ملانوکورتین-4; Melanocortin-4 receptor; Antagonists; GPCR; Food intake; SAR
MTSEA prevents ligand binding to the human melanocortin-4 receptor by modification of cysteine 130 in transmembrane helix 3
Keywords: گیرنده ملانوکورتین-4; GPCR; G protein-coupled receptor; IAA; iodoacetamide; MC; melanocortin; α-MSH; α-melanocyte-stimulating hormone; MTS; methane thiosulfonate; MTSEA; MTS ethylammonium; NEM; N-ethyl maleimide; NDPα-MSH; [Nle4, d-Phe7]α-MSH; SHU9119; acetyl-Nle4-cyclo[As