The contribution of serotonin 5-HT2C and melanocortin-4 receptors to the satiety signaling of glucagon-like peptide 1 and liragultide, a glucagon-like peptide 1 receptor agonist, in mice

► We examine the role of serotonin 5-HT2C receptor and melanocortin 4-receptor (MC4R) in the anorexia induced by GLP-1 and liraglutide, a GLP-1 receptor agonist in mice. ► Systemic administration of GLP-1-induced anorexia was blunted in mice with a 5HT2CR null mutation, and was attenuated in mice with a heterozygous MC4R mutation. ► Systemic administration of liraglutide suppressed food intake in mice lacking 5-HT2CR, mice with a heterozygous mutation of MC4R and wild-type mice matched for age. ► GLP-1 and liraglutide induce anorexia via different central pathways.