کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1361890 | 981473 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of chlorogenic acid derivatives with promising antifungal activity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Derivatives of chlorogenic acid or its analogues were synthesized by coupling protected chlorogenic acid or its analogues with p-octyloxyaniline and selected amino acids. Most of the compounds exhibited significant potency against Cryptococcus neoformans and Candida species with low toxicity to brine shrimps. The 4,5-dihydroxyl groups in the quinic acid moiety were necessary for the activity and introduction of a free amino group increased the inhibitory activity against Aspergillus fumigatus.
The synthesis of the chlorogenic acid derivatives with in vitro antifungal activity is reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 21, 1 November 2007, Pages 6830–6833
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 21, 1 November 2007, Pages 6830–6833
نویسندگان
Chao-Mei Ma, Maureen Kully, Jehangir K. Khan, Masao Hattori, Mohsen Daneshtalab,