Synthesis of diverse analogues of Oenostacin and their antibacterial activities

Several diverse analogues of Oenostacin, a naturally occurring potent antibacterial phenolic acid derivative, have been synthesized. A small library with more than forty analogues having different aromatic rings and varied side chains has been achieved through solution phase synthesis. Some of these analogues, that is, 22, 23 and 42, possessed potent antibacterial activities against Staphylococcus epidermidis and Staphylococcus aureus having EC50 ranging from 0.49 to 0.67 μM as compared to Oenostacin (EC50 = 0.12 μM).

Various synthetic analogues of Oenostacin, a naturally occurring plant lead compound, have been synthesized. Some of the analogues possessed potent antibacterial activities against Staphylococcus epidermidis and Staphylococcus aureus. However, none of these was as active as Oenostacin.Figure optionsDownload as PowerPoint slide