کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1362388 981487 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel naturally occurring tripyrrole with potential nuclease and anti-tumour properties
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A novel naturally occurring tripyrrole with potential nuclease and anti-tumour properties
چکیده انگلیسی

The DNA targeting and membrane damaging activities of a novel tripyrrole 1 obtained as a red pigment from the Micrococcus sp. were investigated. It was found that compound 1 binds with DNA efficiently and facilitates copper-mediated DNA cleavage as well as peroxidation of membrane lipids by a process that does not require any external reducing agent. Compound 1 also showed impressive cytotoxicity to both mouse and human tumour cell lines. The membrane damaging ability of compound 1 might be vital in its nuclease and cytotoxicity properties. Interestingly, compared to the various DNA cleaving agents, compound 1 showed a preferential binding with the G–C rich domain.

The natural tripyrrole 1 shows intercalative DNA binding with high G-C specificity and a Cu(II)-dependent nuclease and lipid damaging abilities. The prooxidant activity also assists in its cytoxicity to tumour cell lines.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 8, 15 April 2006, Pages 2480–2486
نویسندگان
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