کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1362441 | 981488 | 2006 | 8 صفحه PDF | دانلود رایگان |
A series of coumarin derivatives were synthesized in two steps from phloroglucinol. The anti-inflammatory activities of these derivatives were evaluated by means of inhibiting NO production in LPS-induced RAW 264.7 cells. Derivatives 3, 8, 10, 11, and 13 exhibited low micromolar levels of anti-inflammatory activities, and these derivatives also protected DNA against hydroxyl radical attack. Coumarin derivative 8 was the most potent derivative among those tested herein against NO production in LPS-induced RAW 264.7 cells with an IC50 value of 7.6 μM, and it effectively reduced the hydroxyl radical production by 50% at 100 μM in the electron spin resonance study.
A series of coumarin derivatives were synthesized and anti-inflammatory activities evaluated. Coumarin derivative 8 was the most potent derivative against NO production in LPS-induced RAW 264.7 cells with an IC50 value of 7.6 μM and it effectively scavenged the hydroxyl radical production by 50% at 100 μM in the electron spin resonance study.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 13, 1 July 2006, Pages 4402–4409