Enantiomeric N-methyl-4-piperidyl benzilates as muscarinic receptor ligands: Radioligand binding studies and docking studies to models of the three muscarinic receptors M1, M2 and M3

N-Methyl-4-piperidyl benzilates possess high affinity to muscarinic receptors. The binding site on muscarinic receptors (M1-M3) and the effect of structural variations of chiral N-methyl-4-piperidyl benzilates are investigated by molecular modelling and radioligand binding studies. Model of the M1 receptor with the potential binding site (red) for N-methyl-4-piperidyl benzilates depicted from the extracellular site.