کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1362652 981493 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics
چکیده انگلیسی

1,5-Dideoxy-1,5-imino-d-glucitol, the corresponding d-manno and l-ido epimers as well as the powerful β-glucosidase inhibitor isofagomine were N-alkylated with di-, tri-, as well as tetraethylene glycol derived straight chain spacer arms by a set of simple standard procedures. The terminal functional groups of the spacer arms, primary amines, were employed to introduce fluorescent dansyl moieties. Resulting derivatives showed glycosidase inhibitory activities comparable to those of the parent compounds’.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 6, 15 March 2006, Pages 1737–1742
نویسندگان
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