کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1362652 | 981493 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fluorescently tagged iminoalditol glycosidase inhibitors as novel biological probes and diagnostics
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
1,5-Dideoxy-1,5-imino-d-glucitol, the corresponding d-manno and l-ido epimers as well as the powerful β-glucosidase inhibitor isofagomine were N-alkylated with di-, tri-, as well as tetraethylene glycol derived straight chain spacer arms by a set of simple standard procedures. The terminal functional groups of the spacer arms, primary amines, were employed to introduce fluorescent dansyl moieties. Resulting derivatives showed glycosidase inhibitory activities comparable to those of the parent compounds’.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 6, 15 March 2006, Pages 1737–1742
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 6, 15 March 2006, Pages 1737–1742
نویسندگان
Inge Lundt, Andreas J. Steiner, Arnold E. Stütz, Chris A. Tarling, Stefan Ully, Stephen G. Withers, Tanja M. Wrodnigg,