Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives

A series of substituted piperazine derivatives have been synthesized and tested for antimicrobial activity. The antibacterial activity was tested against Staphylococcus aureus (MTCCB 737), Pseudomonas aeruginosa (MTCCB 741), Streptomyces epidermidis (MTCCB 1824) and Escherichia coli (MTCCB 1652), and antifungal activity against Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger. All synthesized compounds showed significant activity against bacterial strains but were found to be less active against tested fungi. In vitro toxicity tests demonstrated that compounds 4d and 6a showed very less toxicity against human erythrocytes.

N-Alkyl and N-aryl derivatives of piperazines have been synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds show potent antibacterial activity and were found to be less active against fungi. Compounds 4d and 6a were found to be very less toxic to human erythrocytes when compared with gentamicin.Figure optionsDownload as PowerPoint slide