Structure–activity relationship study of homoallylamines and related derivatives acting as antifungal agents

The synthesis, in vitro evaluation, and structure–activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.

The synthesis, in vitro evaluation, and SAR studies of homoallylamines and related derivatives acting as antifungal agents are reported. Molecular modeling studies allow us to determine the pharmacophoric patron.Figure optionsDownload as PowerPoint slide