کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1362668 981493 2006 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and comparative molecular field analysis (CoMFA) of argentatin B derivatives as growth inhibitors of human cancer cell lines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and comparative molecular field analysis (CoMFA) of argentatin B derivatives as growth inhibitors of human cancer cell lines
چکیده انگلیسی
Synthesis, anticancer activity, and QSAR of 14 argentatin B analogs are described. Derivative 2-formyl-(16β,24R)-16,24-epoxy-25-hydroxycycloart-1-en-3-one was 35-50 times more potent than argentatin B to inhibit the growth of four human cancer cell lines. 3D-QSAR of K562 cell line growth inhibition was performed using the X-ray crystallographic structures of six derivatives as prototypes. Comparative molecular field analysis showed that a bulky group at C-2, a C1-C2 double bond, and a low electronic density near to C-25 increase the potency of these triterpenes. Experimental Log Ps for argentatin B and one derivative were 1-2 Log units more hydrophilic than the C Log P predicted values.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 6, 15 March 2006, Pages 1889-1901
نویسندگان
, , , , , , ,