New cytotoxic-antineoplastic prenyl-1,2-naphthohydroquinone derivatives

Several new prenylnaphthohydroquinone derivatives have been prepared through the Diels–Alder condensation between α-myrcene and 1,2-benzoquinone and evaluated for their cytotoxic activity against A-549, HT-29 and MB-231 cultured cell lines. All of them have shown GI50 values in the μM level.

A family of prenyl-1,2-naphthohydroquinone derivatives have been synthesized from the acetylated Diels–Alder product 2, of α-myrcene and 1,2-benzoquinone. This family has been evaluated for their cytotoxicity against A-549, HT-29 and MB-231 neoplastic cell lines.Figure optionsDownload as PowerPoint slide