کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1362791 981496 2005 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Triketones active against antibiotic-resistant bacteria: Synthesis, structure–activity relationships, and mode of action
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Triketones active against antibiotic-resistant bacteria: Synthesis, structure–activity relationships, and mode of action
چکیده انگلیسی

A series of acylated phloroglucinols and triketones was synthesized and tested for activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE) and multi-drug-resistant Mycobacterium tuberculosis (MDR-TB). A tetra-methylated triketone with a C12 side chain was the most active compound (MIC of around 1.0 μg/ml against MRSA) and was shown to stimulate oxygen consumption by resting cell suspensions, suggesting that the primary target was the cytoplasmic membrane.

Antibacterial triketones prepared from acylated phloroglucinols showed a range of activities in vitro against MRSA and other drug-resistant bacteria.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 24, 15 December 2005, Pages 6651–6662
نویسندگان
, , , , , , , ,