The synthesis of paleic acid, an antimicrobial agent effective against Mannheimia and Pasteurella, and its structurally related derivatives

A synthetic route to paleic acid 1, antibicrobial agent effective against Mannheimia haemolytica and Pasteurella multocida, has been established. The procedure was also applied to the preparation of structurally related analogs, which were used in structure-activity relationship studies for antibacterial activity.