کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363015 981500 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins
چکیده انگلیسی

A general strategy to enzymatically label acyl carrier proteins (ACPs) of polyketide synthases has been developed. Incorporation of a chloromethyl ketone or vinyl ketone moiety into polyketide chain elongation intermediate mimics allows for the synthesis of CoA adducts. These CoA adducts undergo enzymatic reaction with Sfp, a phosphopantetheinyl transferase, to afford labeled CurB carrier proteins.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 19, 1 October 2010, Pages 5939–5942
نویسندگان
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