کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363071 | 981502 | 2007 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters](/preview/png/1363071.png)
چکیده انگلیسی
A series of simple truncated analogues of phenyl tropanes, 2-arylcycloalk-1-enyl carboxylic acid methylesters, were prepared and investigated for their activity towards the dopamine, serotonin and norepinephrine transporters. The compounds were prepared from cyclic ketoesters, which were converted to enolic triflates and reacted with arylboronates using the Suzuki coupling. For comparison the corresponding piperidines were also made and investigated. The new compounds inhibit monoamine-transporters with Ki values ranging from 0.1 to 1000 μM.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 12, 15 June 2007, Pages 4159–4174
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 12, 15 June 2007, Pages 4159–4174
نویسندگان
Mikkel Due Petersen, Søren Valdgård Boye, Erik Holm Nielsen, Jeanette Willumsen, Steffen Sinning, Ove Wiborg, Mikael Bols,