کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363116 981503 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of chromenochalcones and evaluation of their in vitro antileishmanial activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of chromenochalcones and evaluation of their in vitro antileishmanial activity
چکیده انگلیسی

A large number of novel chromenochalcones were synthesized by pyridine-catalysed chromenylation of mono-chelated meta-dihydric acetophenones with the monoterpene, citral dimethyl acetal and subsequent Claisen–Schmidt condensation of the resultant acylchromenes with appropriate aromatic aldehydes. These chromenochalcones 1–19 were screened against in vitro extracellular promastigotes and intracellular amastigotes of Leishmania donovani. The most potent compound in this series was compound 9 with a pyridine ring-A, which showed 99% inhibition of promastigotes at 10 μg/ml, 82% at 0.25 μg/ml and 96% at 10 μg/ml concentration against amastigotes.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 23, 1 December 2005, Pages 6543–6550
نویسندگان
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