کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363156 | 981504 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A highly sensitive probe detecting low pH area of HeLa cells based on rhodamine B modified β-cyclodextrins
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A highly sensitive probe detecting low pH area of HeLa cells based on rhodamine B modified β-cyclodextrins A highly sensitive probe detecting low pH area of HeLa cells based on rhodamine B modified β-cyclodextrins](/preview/png/1363156.png)
چکیده انگلیسی
Two kinds of rhodamine modified β-cyclodextrins (R-1 and R-2), which are coupled up ethylene diamine (EDA) and tetraethylene pentamine (TEPA) between Rh B and β-cyclodextrin, respectively, have been synthesized. R-1 and 2 work as a new fluorogenic probe for monitoring pH of Hela cells, and MTT of assay R-1, R-2, and rhodamine B indicate that less a cytotoxicity of those R-1 and R-2 than that of rhodamine B, where R-1 has much less one than that of R-2. The fluorogenetic probe capability of R-2 was recognized in an area of acidic area in living cell, which is lysosome.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 16, 15 August 2009, Pages 6015–6019
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 16, 15 August 2009, Pages 6015–6019
نویسندگان
Takuto Hasegawa, Yoshihiko Kondo, Yukio Koizumi, Toshihiro Sugiyama, Akane Takeda, Shinichi Ito, Fumio Hamada,