Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs

Synthesis and biological characterization of a series of α-tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties, and antiplatelet activity. They were also capable of preventing LDL oxidation.

Synthesis and biological characterization of a series of products obtained by coupling α-tocopherol or analogs through appropriate spacers with the NO-donor either nitrooxy or furoxan moieties.Figure optionsDownload as PowerPoint slide