کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1363459 | 981512 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Substitution at the 8-position of 3″-deoxy-cyclic ADP-carbocyclic-ribose, a highly potent Ca2+-mobilizing agent, provides partial agonists1
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Substitution at the 8-position of 3″-deoxy-cyclic ADP-carbocyclic-ribose, a highly potent Ca2+-mobilizing agent, provides partial agonists1 Substitution at the 8-position of 3″-deoxy-cyclic ADP-carbocyclic-ribose, a highly potent Ca2+-mobilizing agent, provides partial agonists1](/preview/png/1363459.png)
چکیده انگلیسی
We previously showed that 3″-deoxy-cyclic ADP-carbocyclic-ribose (3″-deoxy-cADPcR, 4) is a stable and highly potent analogue of cyclic ADP-ribose (cADPR, 1), a Ca2+-mobilizing second messenger. From these results, we designed and synthesized other 3″-modified analogues of cADPcR having a substituent at the 8-position and found that this modification at the 8-position made them partial agonists. Among these compounds, 8-NH2-3″-deoxy-cADPcR (10) was identified as a potent partial agonist with an EC50 value of 17 nM.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 8, 15 April 2007, Pages 3032–3040
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 8, 15 April 2007, Pages 3032–3040
نویسندگان
Takashi Kudoh, Takashi Murayama, Akira Matsuda, Satoshi Shuto,