کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363648 981519 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analog
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analog
چکیده انگلیسی

An albumin-binding prodrug of the extremely potent CC-1065 analog, (+)-FDI-CBI, has been synthesized. This analog, (+)-FDI-CBIM, formed an albumin conjugate when added to human albumin in vitro. A greater amount (>3-fold) of the prodrug can be administered to animals compared to the free drug. The prodrug had significantly improved antitumor efficacy compared to the free drug in animal models using syngeneic animal tumors and human ovarian xenografted tumor cells. Antitumor drug delivery by in situ formation of drug–albumin conjugate is a promising strategy to improve antitumor efficacy.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 13, 1 July 2008, Pages 6552–6559
نویسندگان
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