کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1363836 981522 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A fluorine containing bipyridine cisplatin analog is more effective than cisplatin at inducing apoptosis in cancer cell lines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A fluorine containing bipyridine cisplatin analog is more effective than cisplatin at inducing apoptosis in cancer cell lines
چکیده انگلیسی

Novel cisplatin analogs dichloro[4,4′-bis(4,4,4-trifluorobutyl)-2,2′-bipyridine]platinum (1) and fac-tricarbonylchloro[4,4′-bis(4,4,4-trifluorobutyl)-2,2′-bipyridine]rhenium (3) were synthesized and evaluated for their cytotoxicity. While 3 was not cytotoxic, 1 was 14 to 125 times more lethal than cisplatin in breast, prostate, and lung cancer cell lines. Compound 1 was able to induce apoptosis and the presence of the platinum atom was essential to its function as a cytotoxin.

The synthesis of dichloro[4,4′-bis(4,4,4-trifluorobutyl)-2,2′-bipyridine]platinum (1), a cisplatin analog, and a preliminary study of its cytotoxicity are reported. Compound 1 is 14 to 125 times more effective than cisplatin in inducing apoptosis in breast, lung, and prostate cancer cell lines.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 24, 15 December 2006, Pages 8692–8700
نویسندگان
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