کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1363836 | 981522 | 2006 | 9 صفحه PDF | دانلود رایگان |

Novel cisplatin analogs dichloro[4,4′-bis(4,4,4-trifluorobutyl)-2,2′-bipyridine]platinum (1) and fac-tricarbonylchloro[4,4′-bis(4,4,4-trifluorobutyl)-2,2′-bipyridine]rhenium (3) were synthesized and evaluated for their cytotoxicity. While 3 was not cytotoxic, 1 was 14 to 125 times more lethal than cisplatin in breast, prostate, and lung cancer cell lines. Compound 1 was able to induce apoptosis and the presence of the platinum atom was essential to its function as a cytotoxin.
The synthesis of dichloro[4,4′-bis(4,4,4-trifluorobutyl)-2,2′-bipyridine]platinum (1), a cisplatin analog, and a preliminary study of its cytotoxicity are reported. Compound 1 is 14 to 125 times more effective than cisplatin in inducing apoptosis in breast, lung, and prostate cancer cell lines.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 24, 15 December 2006, Pages 8692–8700